Assessment of the biological effects of the pharmaceutical Losartan on microcrustaceans Daphnia similis and Ceriodaphnia dubia

Nathalia Sayuri Yamamoto, Camilo Dias Seabra Pereira, Fernando Sanzi Cortez, Fabio Hermes Pusceddu, Aldo Ramos Santos, Luciana Lopes Guimarães

Abstract


The Losartan is a widely used antihypertensive that has evidence of occurrence in effluents and environmental matrices (surface water, sediment). Therefore, the present study assessed the acute and chronic toxicity of this compound by means of toxicity tests with the microcrustaceans D. similis and C. dubia, respectively. The acute toxicity tests, conducted in accordance with the NBR 12713/2009, demonstrated a median effective concentration (n=3) of 175.26 mg.L-1. The preliminary test for chronic effect assessment, conducted in accordance with the NBR 133732010, revealed a observed effect concentration (CEO) of 100 mg.L-1. These results demonstrate the unlikely occurrence of ecological risk for Losartan, considering that effect concentrations were greater than those recognized as environmentally relevant. In addition, these data may generate support for the establishment of safe concentrations for this compound in the environmental legislation.

Keywords

Ecotoxicology, pharmaceutical, Losartan, Daphnia similis and Ceriodaphnia dubia.


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