Evaluation of antifungal activity in vitro of semi-purified fractions obtained from rhizome Typha domingensis pers (Typhaceae)

Abstract

In recent years, the field of Pharmacology of Natural Products has demonstrated several bioactive compounds originating from vegetable samples. This fact is strictly related to scientific and technological developments, allowing the expansion of knowledge in the fields of chemistry and pharmacology applied to plant secondary metabolites. The data originated from these researches is expanding exponentially the possibilities of application of plants as a direct source for obtaining pharmaceuticals or inspiring the synthesis of new drugs from molecular structures discoveries. Within this context, the present study aimed to perform phytochemical analysis and evaluate the potential antifungal activity in vitro of 03 semi-purified fractions obtained from the rhizome of Typha domingensis Pers (Typhaceae) in cultures of Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis. The results showed antifungal activity of the semi-purified fraction of ethyl acetate (FrAcE) for the four species of Candida spp tested, with MFC values of 10 mg/mL. Phytochemical analysis revealed the presence of flavonoids in FrAcE, class of plant secondary metabolites with antifungal activity previously described. The data generated from this study may serve as support for further studies that might contribute to the development of new antifungal therapies based on the antifungal properties from the rhizome of Typha domingensis.

Keywords: Typha domingensis; Antifungal Activity; Candida spp; Flavonoids.